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David Eastwood Selected Research

TGN-1412 (TGN1412)

6/2015An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics.
8/2013Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.
8/2011Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.
7/2011Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.
9/2007"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.

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David Eastwood Research Topics

Disease

4Cytokine Release Syndrome
06/2015 - 09/2007
2Necrosis
08/2011 - 01/2010
1Poliomyelitis (Polio)
10/2014

Drug/Important Bio-Agent (IBA)

5TGN-1412 (TGN1412)IBA
06/2015 - 09/2007
2Alemtuzumab (Campath)FDA Link
06/2015 - 08/2011
2AntibodiesIBA
08/2011 - 01/2010
1Formaldehyde (Formol)FDA Link
10/2014
1VaccinesIBA
10/2014
1Interleukin-2 (IL2)IBA
08/2013
1Trastuzumab (Herceptin)FDA Link
08/2011
1Interleukin-6 (Interleukin 6)IBA
08/2011
1CytokinesIBA
07/2011
1Monoclonal AntibodiesIBA
07/2011